Alpha Omega Engineering Ltd.

www.alphaomega-eng.com

High-Tech Company

TECH VERTICALS

B2C, Healthtech, Life Sciences, Medical Devices, MedTech, Neuroscience

General Data

Sector	Medical Devices
Company Stage:	Revenue Growth
Established	1993
Number of Employees	150
Employees in Israel	75
Reg. Number:	abCDe

DESCRIPTION

Alpha Omega Engineering develops and manufactures advanced neurosurgical systems for neural Navigation, primarily used in the treatment of neurological disorders. Alpha Omega is a recognized leader in equipment and algorithms supporting Deep Brain Stimulation (DBS) procedures, with a broad installed base in leading hospitals and neuroscience centers worldwide including Mayo Clinic, NYU, Massachusetts General Hospital, University of Freiburg and Charité Universitätsmedizin Berlin.
Alpha Omega’s portfolio includes novel technologies that enable accurate, simple, and effective electrode placement in the brain, real-time recording and processing of neural activity, and precise stimulation of neuronal targets.
The company's vision is for Alpha Omega solutions to be present in every neurosurgery department, enabling optimal treatment for every patient.
AO strives to create a workplace where people from divided communities work side by side without losing who they are. AO has more than 150 employees working together with main offices in Nazareth, Jenin, Atlanta, Heidelberg, and Guangzhou.

TECHNOLOGY

Neural signal acquisition and processing, real-time navigation and targeting algorithms, Microelectrode Recording (MER), motorized and manual micromanipulators, Physiological Navigation Systems (PNS), neurostimulation and stimulation isolators, software-hardware integrated neurosurgical platforms, electrodes and intraoperative probes for recording, stimulating, and analyzing brain activity and tissue.

Products and Phases

Product	Phase
HaGuide	FDA Approved CE Approved NMPA, TGA, PMDA, AMAR
HaGuide is a semi-automatic navigation software that supports real-time decision-making during DBS procedures. Using microelectrode recording (MER)–based analysis, HaGuide identifies STN entry and exit points, detects subregion boundaries, and recommends optimal stimulation locations. The solution is integrated with AO’s intraoperative platforms, supporting accurate and consistent target localization.
NeuroFortis Drive HeadStage	FDA Approved CE Approved NMPA, TGA, PMDA, AMAR
NeuroFortis is a motorized drive and headstage designed for intraoperative DBS procedures. It supports precise electrode advancement with integrated recording and stimulation, and is compatible with AO’s intraoperative platforms and surgical workflows.
Neuro Omega Pro	FDA Approved CE Approved
Neuro Omega PRO is AO’s flagship intraoperative neurophysiology and navigation platform for functional neurosurgery. The system integrates advanced intraoperative neural navigation, stimulation, and data analysis to support accurate target localization during DBS and other functional procedures. It is widely installed in leading neurosurgical centers worldwide.
ɑ lphaRS
alphaRS serves as a core electrophysiology platform for research and clinical electrophysiology workflows. It is a flexible neural data acquisition and stimulation system that supports integrated recording and stimulation across a scalable number of channels.
LeadConfirm	FDA Approved CE Approved TGA, AMAR
LeadConfirm is a disposable confirmation solution used to verify the DBS lead placement during procedures. It supports real-time confirmation of optimal location, enhancing procedural confidence and efficiency per patient.
AlphaProbe	FDA Approved CE Approved TGA, AMAR
AlphaProbe is a multi-contact directional navigation probe designed for neuroal navigation during DBS procedures. A single probe provides functionality equivalent to multiple microelectrodes, enabling single-pass target localization and structure boundary identification using combined recording and stimulation, and integrates with AO’s navigation software for real-time analysis.

	TARGET MARKETS
	Neurosurgeons, movement disorder specialists, neurologists, physiologists, and other professionals in neurosurgery and neurology departments, hospitals, research institutions, and neuroscience laboratories. AO also serves patients and caregivers through consumer-facing products such as wearables and applications.

	BUSINESS MODEL
	B2B

Patents

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Publication ID/Number

Patent Title

Status

Initial Filing Date

US11051889B2

Brain navigation methods and device

Granted

Jul. 07, 2017

Grant Date	Jul. 06, 2021
Jurisdictional Coverage	US
Technology Classification	A61B34/20
Description	A system for differential recording includes an electrical lead with at least two electrodes, at least one amplifier for subtracting signals from the electrodes to generate a differential signal, a memory for storing the differential signal and reference signals associated with neural tissue, and processing circuitry to determine the anatomical position based on the differential signal and reference indications.
Expiration Date	Oct. 13, 2036
Publication Date	Jul. 06, 2021
Rejection Date
Web Link	https://patents.google.com/patent/US11051889B2/en?q=(Alpha+Omega+Engineering+younis)&oq=Alpha+Omega+Engineering+younis
Remarks

US7917231B2

Directional stimulation of neural tissue

Granted

Feb. 27, 2008

Grant Date	Mar. 29, 2008
Jurisdictional Coverage	ES EP US
Technology Classification	A61N1/36082
Description	A multi-contact electrode for neural tissue stimulation is described. The electrode has an axis and includes a plurality of electrodes going along the axis. Each electrode ends with a contact, and at least one of the contacts has an internal edge, resulting in non-uniform electrical properties throughout the contact surface facing the tissue. Also described are methods of making an electrical contact with an internal edge, and methods and systems for characterizing internal edge.
Expiration Date	Aug. 17, 2028
Publication Date	Mar. 29, 2011
Rejection Date
Web Link	https://patents.google.com/patent/US7917231B2/en?q=(Alpha+Omega+Engineering+younis)&oq=Alpha+Omega+Engineering+younis
Remarks

COMPETITORS

Inomed , FHC

SERVICE PROVIDERS

Company Name	Type
abC Defghij	Patent Attorneys
abC Defghij	Accounting Firm

CONTACT INFO

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Main Address: Nof Hagalil, Israel

Address	6 Hamerkava St., Ziporit Industrial Zone
POB	810
City	Nof Hagalil
Country	Israel
Zip	1789062

Contact Person	abC Defghij
Contact E-Mail	abC Defghij
Company E-mail	abC Defghij
Telephone	abC Defghij
Fax	abC Defghij

Branch Address: Norcross, United States

Address	3160 Campus Drive-Suite 200
City	Norcross
State/Province	GA
Country	United States
Zip	30017

Contact Person	abC Defghij
Contact E-Mail	abC Defghij
Company E-mail	abC Defghij
Telephone	abC Defghij
Fax	abC Defghij

Branch Address: Ubstadt-Weiher, Germany

Address	28 Ubstadter St.
City	Ubstadt-Weiher
Country	Germany
Zip	76698

Contact Person	abC Defghij
Contact E-Mail	abC Defghij
Company E-mail	abC Defghij
Telephone	abC Defghij
Fax	abC Defghij

	MANAGEMENT

Key Executive

Name	Title	Previous Position
Mr. Imad Younis	President & Co-Founder
Mr. Ajwad Akashi	COO
Ms. Reem Younis	Co-Founder
Mr. Mulham Jabaly	CFO
Mr. Nabeel Sakran	VP, R&D	Apple Israel (Director of VLSI)
Ms. Efrat Shamgar	VP, Quality & Regulatory Affairs
Mr. George Evagoras	VP, General Manager
Ms. Dima Younis	Marketing Manager

	BOARD

Board

Member	Title	Affiliation
abC Defghij	Board Member	President & CEO, Co-Founder, Alpha Omega Engineering Ltd.
abC Defghij	Board Member	Co-Founder, Alpha Omega Engineering Ltd.

	FINANCIAL ROUNDS

Total Capital Raised
abCDe

Financial Rounds

Numbers of Investors

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Round

Date

Stage

Amount

Valuation

First Round

Dec. 11, 2018

Revenue Growth

abCDe

For the purpose of establishing a joint venture in China. The investment will not change the ownership structure of Alpha Omega.

* New investor

Investor	Type	Amount	Remarks
abC Defghij	Venture Capital Fund	abCDe

	R&D Grants

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Round

Date

Stage

Amount

Remarks

R&D Grant

Jun. 01, 2019

Revenue Growth

abCDe

* New investor

Investor	Type	Amount	Remarks
abC Defghij	Government Agency	abCDe

R&D Grant

Jun. 01, 2018

Revenue Growth

abCDe

* New investor

Investor	Type	Amount	Remarks
abC Defghij*	Government Agency	abCDe

Last Updated:	abCDe
IVC Number:	abCDe